Although useful for studying molecular mechanisms, animal models provide only a limited representation of human disorders and do not account for patient-specific variations. To address this challenge and to replace animal models, we developed patient specimens-derived model systems including ex vivo organ models, 3D organoids and 2D in vitro cell models.
Our experimental research is based exclusively on the so-called 3R principle (Replace, Reduce, Refine). This ethical concept serves to minimize animal testing by promoting the replacement of animal testing with alternative methods, the reduction of the number of animals required, and the refinement of experimental conditions to ensure maximum animal welfare. The ICGH is part of the 3R Network Baden-Württemberg, which makes a central contribution to improving animal welfare in research and teaching. Our approach ensures that scientific knowledge is acquired in accordance with the highest ethical standards.
Here are the three aspects in detail:
1. Replace: Animal testing should be replaced entirely if there are suitable alternative methods for answering the scientific question. These include, for example, in vitro or ex vivo cell models, 3D organoids, organ-on-a-chip, etc.
2. Reduce: If animal testing is unavoidable, the number of animals used should be kept to the necessary minimum to achieve meaningful scientific results.
3. Refine: Animal testing should be designed to minimize animal suffering and distress. This can be achieved by improving housing conditions, using gentler treatment and anesthesia methods, or less invasive techniques. The aim is to minimize the stress and discomfort of the animals as much as possible and to promote their well-being.
In addition, we are committed to teaching in order to establish the 3R principle firmly in the university landscape.