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Welcome to ICGH

Learn more about our work in the field of gut health and meet our interdisciplinary team of scientists, physicians, bioinformaticians and biostatisticians.

Neuigkeiten & Termine

Hier können Sie sich über bevorstehende Veranstaltungen informieren, erfahren mehr über aktuelle Pressemeldungen & Neuigkeiten des Interdisziplinären Zentrums für Darmgesundheit..
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Who are we? Our team introduced.

The Interdisciplinary Center for Gut Health (ICGH) brings together experts from multiple disciplines to advance complementary research in the field of gut health.
Our interdisciplinary team comprises scientists, physicians, bioinformaticians and biostatisticians with various fields of expertise, including human molecular genetics, developmental biology, stem cell research, immunology, infectiology, gastroenterology, psychosomatics, surgery, endoscopy, pathology, bioinformatics and biostatistics. Most team members are located at research institutions in the cities of Heidelberg and Mannheim in the Rhine-Neckar Metropolitan Region in the federal state of Baden-Württemberg. Further members are based in the adjacent federal states of Rhineland-Palatinate and Bavaria. Our experimental portfolio is optimally complemented by Core Facilities of Heidelberg University and the University Hospitals in both Heidelberg and Mannheim, as well as collaboration partners.
Our team aims to unravel molecular causes of gastrointestinal diseases like Hirschsprung disease, irritable bowel syndrome and chronic inflammatory bowel diseases such as Crohn disease and Ulcerative colitis. Furthermore, we have recently started focusing our research on extra-intestinal disorders, such as autism spectrum disorders and Parkinson disease.
The ICGH is one of five centers that form the basic framework of the 3R Network Baden-Württemberg and are funded by the Ministry of Science, Research and the Arts of Baden-Württemberg. The 3R principle is anchored in the German Animal Protection Act and stands for replacement, as in the case of the ICGH, reduction and refinement of animal experiments.
The Interdisciplinary Center for Gut Health (ICGH) brings together experts from multiple disciplines to advance complementary research in the field of gut health.

Our team

Dr. rer. nat. Stefanie Schmitteckert
Interim project lead
Human Genetics
Institute of Human Genetics
Heidelberg University Hospital
Im Neuenheiner Feld 366
69120 Heidelberg
Prof. Dr. rer. nat. Beate Niesler
Project Lead
Human Genetics
Institute of Human Genetics
Heidelberg University Hospital
Im Neuenheiner Feld 366
69120 Heidelberg
Dipl. Ing. Ralph Röth
Assistant project lead
Human Genetics
Institute of Human Genetics
Heidelberg University Hospital
Im Neuenheiner Feld 366
69120 Heidelberg
Prof. Dr. med. Peter Kienle
Gastroenterology/Surgery
General and Visceral Surgery
Theresien Hospital und St. Hedwig-Clinics GmbH Mannheim
Bassermannstraße 1
68165 Mannheim
Prof. em. Dr. med. Dr. h.c. Lucas Wessel
Surgery
Pediatric Surgery Clinic
University Hospital Mannheim
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
Prof. Dr. med. Annika Gauß
Gastroenterology
Department of Gastroenterology and Hepatology
Heidelberg University Hospital
Im Neuenheimer Feld 410
69120 Heidelberg
Prof. Dr. med. Robert Ehehalt
Gastroenterology
Gastroenterology practice
Bergheimerstr. 59-61
69115 Heidelberg
Prof. Dr. med. Anja Schaible
Endoscopy
Department of General, Visceral and Transplantation Surgery
Heidelberg University Hospital
Im Neuenheimer Feld 410
69120 Heidelberg
Prof. Dr. med. Ronald Koschny
Endoscopy
Department of General, Visceral and Transplantation Surgery
Heidelberg University Hospital
Im Neuenheimer Feld 410
69120 Heidelberg
Prof. Dr. med. Michael Böttcher
Surgery
Pediatric Surgery Clinic
University Hospital Mannheim
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
Dr. med. Philipp Romero
Surgery
Division of Pediatric Surgery
Department of General, Visceral and Transplantation Surgery
Heidelberg University Hospital
Im Neuenheimer Feld 430
69120 Heidelberg
Prof. Dr. med. Patrick Günther
Surgery
Division of Pediatric Surgery
Department of General, Visceral and Transplantation Surgery
Heidelberg University Hospital
Im Neuenheimer Feld 430
69120 Heidelberg
Prof. Dr. rer. nat. Jan Korbel
Applied Bioinformatics
Genome Biology Unit (EMBL)
Meyerhofstrasse 1
69117 Heidelberg
PD Dr. med. Steffen Seyfried
Surgery
Department of Surgery
Mannheim University Hospital
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
Dr. med. Anne Thomann
Gastroenterology
Department of Medicine II
Mannheim University Hospital
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
PD Dr. med. Wolfgang Reindl
Gastroenterology
Department of Medicine II
Mannheim University Hospital
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
Dr. med. Jutta Schröder-Braunstein
Immunology
Institute of Immunology
University of Heidelberg
Im Neuenheimer Feld 305
69120 Heidelberg
Dr. med. Sabrina Klein
Medical Microbiology and Hygiene
Department of Infectious Diseases
Heidelberg University Hospital
Im Neuenheimer Feld 324
69120 Heidelberg
Dr. med. My-Lan Kha
Medical Microbiology and Hygiene
Department of Infectious Diseases
Heidelberg University Hospital
Im Neuenheimer Feld 324
69120 Heidelberg
Dr. med. Fabian Doyon
Surgery
General and Visceral Surgery
Theresien Hospital und St. Hedwig-Clinics GmbH Mannheim
Bassermannstraße 1
68165 Mannheim
Dr. rer. nat. Nagarajan Paramasivam
Computational Oncology
Molecular Precision Oncology Program
Molecular Diagnostics Program, National Center for Tumor Diseases (NCT) Heidelberg
Im Neuenheimer Feld 460
69120 Heidelberg
Dr. rer. nat. Dr. med. Daniel Huebschmann
Applied Bioinformatics
Heidelberg Institute for Stem cell Technology and Experimental Medicine (HI-STEM)
German Cancer Research Center (DKFZ) Heidelberg
Im Neuenheimer Feld 280
69120 Heidelberg
Computational Oncology
Molecular Precision Oncology Program
Molecular Diagnostics Program, National Center for Tumor Diseases (NCT) Heidelberg
Im Neuenheimer Feld 460
69120 Heidelberg
Prof. Dr. rer. nat. Justo Lorenzo-Bermejo
Biostatistics
Institute of Medical Biometry and Informatics
University of Heidelberg
Im Neuenheimer Feld 130.3
69120 Heidelberg
Prof. Dr. med. Jonas Tesarz
Psychosomatics
Department of General Internal Medicine and Psychosomatics
University Hospital Heidelberg
Im Neuenheimer Feld 410
69120 Heidelberg
Dr. med. Felicitas Engel
Psychosomatics
Department of General Internal Medicine and Psychosomatics
University Hospital Heidelberg
Im Neuenheimer Feld 410
69120 Heidelberg
Prof. Dr. rer. nat. Stephanie Rössler
Pathology
Institute of Pathology
Heidelberg University Hospital
Im Neuenheimer Feld 224
69120 Heidelberg
Dr. med. Constantin Schwab
Pathology
Institute of Pathology
Heidelberg University Hospital
Im Neuenheimer Feld 224
69120 Heidelberg
Jutta Scheuerer
Pathology
Institute of Pathology
Heidelberg University Hospital
Im Neuenheimer Feld 224
69120 Heidelberg
Dr. rer. nat. Martin Resnik Docampo
Immunology
BioMed X Institute
Im Neuenheimer Feld 515
69120 Heidelberg
Prof. Dr. med. Karl-Herbert Schäfer
Research
Department of Informatics and Microsystems and Technology
University of Applied Science Kaiserslautern
Working Group Enteric Nervous System
Amerikastr. 1
66482 Zweibrücken
Pediatric Surgery Clinic
University Hospital Mannheim
Theodor-Kutzer-Ufer 1-3
68167 Mannheim
Dr. rer. nat. Manuela Gries
Research
Department of Informatics and Microsystems and Technology
University of Applied Science Kaiserslautern
Working Group Enteric Nervous System
Amerikastr. 1
66482 Zweibrücken
M.Sc. Steven Schulte
Research
Department of Informatics and Microsystems and Technology
University of Applied Science Kaiserslautern
Working Group Enteric Nervous System
Amerikastr. 1
66482 Zweibrücken
Antje Heidtmann
Immunology
Institute of Immunology
University of Heidelberg
Im Neuenheimer Feld 305
69120 Heidelberg

Clinical teams

Learn more about the focus areas of our clinical teams.
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Basic research team

Learn more about our basic research teams and their work.
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Bioinformatics / Biostatistics team

Find out more about the data analytics teams.
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Further partners of ICGH

Read more about our collaboration partners.
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Our mission

We consider ourselves a collaboration platform of complementary disciplines, essentially combining clinical and basic research, as well as bioinformatics and biostatistics. We apply complementary research approaches, modeling of human diseases in the cell culture dish, translational approaches - from lab to bedside, detailed phenotyping of patients as well as complex integrative data analyses.
In particular, we aim to investigate the underlying molecular disturbances of the enteric nervous system, the immune and the intestinal barrier function in intestinal disorders using appropriate human cell models. In the long term, we plan to generate patient-specific 3D organoids from corresponding intestinal epithelial, immune, and neuronal cells in which individual organ functions can be reproduced and studied in detail. These analyses will be complemented by detailed phenotyping of patients and the collection of clinical data. Finally, the collected data will help us to better understand the underlying pathomechanisms in a holistic way and to support the development of alternative therapeutic options.
Support our mission
Deciphering molecular pathomechanisms
to understand and treat underlying molecular disturbances that contribute to the development of intestinal disorders.
Improve diagnostics & therapy
to enable patients to lead symptom-free or almost symptom-free lives suffering from distressing and even life-threatening disorders.
Individual & social benefit
Our overall goal is to support patients and their families to achieve a better gut health, to improve their quality of life and, in the long term, to reduce costs to our healthcare system and society.

Our research approach & expertise

The regulation of intestinal homeostasis is complex and many gastrointestinal diseases are often caused by an impaired function of the enteric nervous system, as well as an overreaction of the immune system due to impaired intestinal barrier function (leaky gut).
Data suggests that the individual genetic background, in interaction with an individual intestinal microbiota, can impair intestinal barrier function, alter the nervous and immune system, and thus affect intestinal homeostasis. This can contribute to various gastrointestinal, as well as extra-intestinal disorders, ranging from irritable bowel syndrome to inflammatory bowel disease, neurodevelopmental disorders, neurodegenerative diseases and even cancer.
Our goal is to establish complementary analyses of compartment-specific regulation at the gene and protein level to contribute to a better understanding of pathogenic processes in intestinal diseases. We aim to identify biomarkers and sub-groups of patients to advance the development of new diagnostic methods and ultimately promote alternative as well as patient-specific therapeutic approaches.
Current publications

Would you like to contact us or support our mission?

Are you yourself affected or a colleague interested in a collaboration? We are looking forward to your message!
You would like to support our mission? Your donation would be appreciated!
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News & press releases

What's new? In current press reports you can learn even more about us and our work.
February 8, 2021
Nationwide network advances animal welfare and research

With the establishment of a comprehensive 3R network covering all major biomedical sites in the state, Baden-Württemberg is taking a new approach to improving scientific research and animal welfare in equal measure ...


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May 12 & 13, 2022
First annual Meeting of the 3R-Network Baden-Württemberg

On May 12th + 13th, 2022, the 3R-Center Tübingen organized on behalf of the Baden-Württemberg Ministry of Science, Research and the Arts (MWK) for the first time the two-day 3R-Annual Conference of the 3R-Network Baden-Württemberg on the topic Replacement, Reduction and Refinement3R of animal testing. With exciting keynote lectures, oral and poster presentations, the event in the Old Anatomy of the Medical Faculty of the Eberhard Karls University of Tübingen offered plenty of opportunities for interdisciplinary exchange between 3R-actors from different disciplines and thus represented an important contribution to better networking among Baden-Württemberg researchers as well as to the professional dialogue among each other.


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January 20, 2023
The 3R-Network Baden Württemberg – Strong Partners, Strong Projects

To ensure that animal welfare is continuously addressed in research, education and training, politics as well as by the general public, the biomedical expertise of researchers in the state is bundled in the 3R-Network Baden-Württemberg and the visibility of the activities is increased for example through public relations work or special course offerings for education and training. The basic framework of the network is formed by five 3R-Centers, each of which acts as a kind of crystallization core for the further expansion of the network. The work of the centers is complemented by Baden-Württemberg researchers who are pursuing three research projects as well as two educational projects in order to structurally anchor replacement- and supplementary methods and the 3R-Principle.


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March 4, 2021
New Baden-Wuerttemberg network to reduce animal testing

With the aim of reducing the number of animal experiments and further improving animal welfare, a new network is being created in Baden-Württemberg ...


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May 4, 2021
Kick-off event of the 3R Network Baden-Württemberg

For the virtual kick-off event of the 3R Network Baden-Württemberg, the Ministry of Science, Research and the Arts, the 3R Center for In Vitro Models and Animal Experimentation Alternatives and the Medical Faculty of the University of Tübingen have invited. (german)


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June 25, 2021
IZDG in the media

Article in the DUZ: There is another way: It does not always have to be animal testing...


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Events

Learn more about upcoming events we are participating in and other important dates.
June, 05-07, 2024
Save the date: WI3R Symposium Würzburg, 5-7th of June 2024

The recently founded Würzburg Initiative 3R (WI3R) has announced its 1st International Conference taking place on the 5-7th of June 2024 at the Rudolf Virchow Center in Würzburg (Germany). WI3R bundles the Bavarian activities in the field of 3R from science, regulatory authorities and industry and networks with existing 3R centers in Germany, Europe and worldwide. The event is co-organized by the Fraunhofer TLC-RT, the German Research Foundation (DFG) funded research clusters SFB/TRR 225 ("From the fundamentals of biofabrication towards functional tissue models"), GRK2157 (3D-Infect) and SFB 1583 (Decide) of University Hospital and University of Würzburg as a joint event. Within the 1st WI3R symposium the German Research Foundation (DFG) will grant the 10th anniversary of the Ursula M. Händel Animal Welfare Prize. The prize recognizes scientists who have made exemplary and sustained efforts to improve the welfare of animals in research. The €80,000 prize is currently the largest prize of its kind in Germany, awarded every two years. Please find more information about the objectives of the event, the speakers and the preliminary program on the webpage.


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June 15 & 16, 2023
Safe the Date: next 3R Annual Conference of the 3R-Network Baden-Württemberg Heidelberg and Mannheim

On June 15th and 16th 2023, the ICGH and the 3R Center Rhein Neckar are organizing on behalf of the Baden-Württemberg Ministry of Science, Research and the Arts (MWK) the second 3R-Annual Conference of the 3R-Network Baden-Württemberg in Heidelberg and Mannheim. Further information will be provided soon.


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May 12 & 13, 2021
Annual Conference 2022 of the 3R Network Baden-Württemberg

The annual conference 2022 of the 3R-Network Baden-Württemberg will take place this year on May 12 and 13, 2022 in Tübingen. In the course of the event, the scientists funded by the Ministry of Science, Research and the Arts (MWK) Baden-Württemberg will present their respective project progress. In addition to these reports from the ten groups funded to date, the conference will provide ample opportunity for interdisciplinary exchange, exciting poster presentations, constructive discussions and networking activities, in addition to presentations by renowned (inter)national 3R experts. Young researchers from the 3R field are especially invited to attend.

We are looking forward to an exciting conference program with leading (inter)national experts sharing and discussing their latest advances around the 3Rs.

More information at: https://www.the3rs.uni-tuebingen.de/3r-konferenz/


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Partners & self-help groups

self-help groups
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